Detalles de la búsqueda
1.
Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering? An investigation of the advantages and pitfalls of post-filtering.
J Mol Graph Model
; 26(8): 1237-51, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18203638
2.
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J Med Chem
; 60(2): 767-786, 2017 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27983835
3.
Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies.
Protein Sci
; 12(3): 501-9, 2003 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12592020
4.
Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies.
J Med Chem
; 45(2): 292-303, 2002 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11784134
5.
Interaction of artemisinin and its related compounds with hydroxypropyl-beta-cyclodextrin in solution state: experimental and molecular-modeling studies.
J Pharm Sci
; 92(3): 649-55, 2003 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12587126
6.
Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem
; 15(12): 4057-68, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17449253
7.
Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem
; 15(3): 1448-74, 2007 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17113777
8.
Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3.
Bioorg Med Chem
; 14(2): 544-59, 2006 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16213143
9.
A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1' side chains.
Bioorg Med Chem
; 14(15): 5303-15, 2006 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16621572
10.
Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.
Bioorg Med Chem
; 13(18): 5371-90, 2005 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16054370
11.
Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines.
Bioorg Med Chem
; 11(10): 2293-9, 2003 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12713840
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